Improvement of tics after subthalamic nucleus deep brain stimulation
I Martinez-Torres, MI Hariz, L Zrinzo, T Foltynie… - Neurology, 2009 - AAN Enterprises
I Martinez-Torres, MI Hariz, L Zrinzo, T Foltynie, P Limousin
Neurology, 2009•AAN EnterprisesDiscussion. Coexistence of TS and PD has previously been described, with the evolution of
PD or dopaminergic medication having variable effects on TS manifestations. 4 Although the
more than 50% reduction in dopaminergic medication could in part explain the improvement
of tics, the immediate deterioration in tics frequency after switching off the stimulation
suggests a direct impact of STN stimulation. The remaining improvement observed in the off-
stimulation assessment compared to preoperative could be explained by a long-term tic …
PD or dopaminergic medication having variable effects on TS manifestations. 4 Although the
more than 50% reduction in dopaminergic medication could in part explain the improvement
of tics, the immediate deterioration in tics frequency after switching off the stimulation
suggests a direct impact of STN stimulation. The remaining improvement observed in the off-
stimulation assessment compared to preoperative could be explained by a long-term tic …
Discussion.
Coexistence of TS and PD has previously been described, with the evolution of PD or dopaminergic medication having variable effects on TS manifestations. 4 Although the more than 50% reduction in dopaminergic medication could in part explain the improvement of tics, the immediate deterioration in tics frequency after switching off the stimulation suggests a direct impact of STN stimulation. The remaining improvement observed in the off-stimulation assessment compared to preoperative could be explained by a long-term tic-suppressant effect of STN DBS, as stimulation was left off only for 15 minutes. A microlesion effect could account for the amelioration reported by the patient prior to stimulation onset.
American Academy of Neurology