Smoking cessation and weight loss after chronic deep brain stimulation of the nucleus accumbens: therapeutic and research implications: case report

M Mantione, W van de Brink, PR Schuurman… - Neurosurgery, 2010 - journals.lww.com
OBJECTIVE: Smoking and overeating are compulsory habits that are difficult to stop. Several
studies have shown involvement of the nucleus accumbens in these and other addictive
behaviors. In this case report, we describe a patient who quit smoking and lost weight
without any effort, and we review the underlying mechanisms of action. CLINICAL
PRESENTATION: A 47-year-old woman presented with chronic treatment-refractory
obsessive-compulsive disorder, nicotine dependence, and obesity. INTERVENTION: The …