The dentate gyrus has long been a focal point for studies on the molecular, cellular, and
network mechanisms responsible for epileptogenesis in temporal lobe epilepsy (TLE).
Although several hypothetical mechanisms are considered in this chapter, two that have
garnered particular interest and experimental support are:(1) the selective loss of vulnerable
interneurons in the region of the hilus and (2) the formation of new recurrent excitatory
circuits after mossy fiber sprouting. Histopathological data show that specific GABAergic …