[HTML][HTML] Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology
SJ James, S Melnyk, M Pogribna, IP Pogribny… - The Journal of …, 2002 - Elsevier
Chronic nutritional deficiencies in folate, choline, methionine, vitamin B-6 and/or vitamin B-
12 can perturb the complex regulatory network that maintains normal one-carbon
metabolism and homocysteine homeostasis. Genetic polymorphisms in these pathways can
act synergistically with nutritional deficiencies to accelerate metabolic pathology associated
with occlusive heart disease, birth defects and dementia. A major unanswered question is
whether homocysteine is causally involved in disease pathogenesis or whether …
12 can perturb the complex regulatory network that maintains normal one-carbon
metabolism and homocysteine homeostasis. Genetic polymorphisms in these pathways can
act synergistically with nutritional deficiencies to accelerate metabolic pathology associated
with occlusive heart disease, birth defects and dementia. A major unanswered question is
whether homocysteine is causally involved in disease pathogenesis or whether …
