Aging is associated with an overall loss of function at the level of the whole organism that
has origins in cellular deterioration. Most cellular components, including mitochondria,
require continuous recycling and regeneration throughout the lifespan. Mitochondria are
particularly susceptive to damage over time as they are the major bioenergetic machinery
and source of oxidative stress in cells. Effective control of mitochondrial biogenesis and
turnover, therefore, becomes critical for the maintenance of energy production, the …