[HTML][HTML] Liver X receptor-retinoid X receptor (LXR-RXR) heterodimer cistrome reveals coordination of LXR and AP1 signaling in keratinocytes
Liver X receptors (LXRs) play a critical role in regulating lipid synthesis and transport in
numerous tissues. In the skin, activation of LXR induces keratinocyte differentiation and
improves epidermal permeability barrier homeostasis. To elucidate the mechanism of LXR
action in skin, we mapped its cistrome by identifying LXRβ-RXRα binding sites using ChIP-
on-chip in normal human epidermal keratinocytes (NHEKs). The cistrome was integrated
with transcription data to obtain a global view of LXR action in keratinocyte biology. Here, we …
numerous tissues. In the skin, activation of LXR induces keratinocyte differentiation and
improves epidermal permeability barrier homeostasis. To elucidate the mechanism of LXR
action in skin, we mapped its cistrome by identifying LXRβ-RXRα binding sites using ChIP-
on-chip in normal human epidermal keratinocytes (NHEKs). The cistrome was integrated
with transcription data to obtain a global view of LXR action in keratinocyte biology. Here, we …
