[HTML][HTML] Coregulated ataxia telangiectasia-mutated and casein kinase sites modulate cAMP-response element-binding protein-coactivator interactions in response to …
NP Shanware, AT Trinh, LM Williams… - Journal of biological …, 2007 - ASBMB
The cyclic AMP-response element-binding protein (CREB) is a bZIP family transcription
factor implicated as an oncoprotein and neuron survival factor. CREB is activated in
response to cellular stimuli, including cAMP and Ca 2+, via phosphorylation of Ser-133,
which promotes interaction between the kinase-inducible domain (KID) of CREB and the
KID-interacting domain of CREB-binding protein (CBP). We previously demonstrated that
the interaction between CREB and CBP is inhibited by DNA-damaging stimuli through a …
factor implicated as an oncoprotein and neuron survival factor. CREB is activated in
response to cellular stimuli, including cAMP and Ca 2+, via phosphorylation of Ser-133,
which promotes interaction between the kinase-inducible domain (KID) of CREB and the
KID-interacting domain of CREB-binding protein (CBP). We previously demonstrated that
the interaction between CREB and CBP is inhibited by DNA-damaging stimuli through a …