[HTML][HTML] The Transcriptional Elongation Inhibitor 5, 6-Dichloro-1-β-D-ribofuranosylbenzimidazole Inhibits Transcription Factor IIH-associated Protein Kinase (∗)
K Yankulov, K Yamashita, R Roy, JM Egly… - Journal of Biological …, 1995 - ASBMB
Regulation of chain elongation by RNA polymerase II can have an important effect on gene
expression (Bentley, D.(1995) Curr. Opin. Genet. Dev. 5, 210-216; Yankulov, K., Blau, J.,
Purton, T., Roberts, S., and Bentley, D.(1994) Cell 77, 749-759); however the mechanisms
that control this step in transcription are not well understood. The adenosine analogue 5, 6-
dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) has long been used as an inhibitor of
RNA polymerase II elongation, but its target is not known. We show that DRB is a potent …
expression (Bentley, D.(1995) Curr. Opin. Genet. Dev. 5, 210-216; Yankulov, K., Blau, J.,
Purton, T., Roberts, S., and Bentley, D.(1994) Cell 77, 749-759); however the mechanisms
that control this step in transcription are not well understood. The adenosine analogue 5, 6-
dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) has long been used as an inhibitor of
RNA polymerase II elongation, but its target is not known. We show that DRB is a potent …