The many roles of an RNA editor
Nature Reviews Genetics, 2001•nature.com
The availability of complete genome sequences has made it clear that gene number is not
the sole determinant of the complexity of the proteome. Additional complexity that is not
readily detected by genome analysis is present in the number and types of RNA transcript
that can be derived from each locus. Although alternative splicing is a well-recognized
method of generating diversity, the more subtle mechanism of RNA editing is less familiar.
the sole determinant of the complexity of the proteome. Additional complexity that is not
readily detected by genome analysis is present in the number and types of RNA transcript
that can be derived from each locus. Although alternative splicing is a well-recognized
method of generating diversity, the more subtle mechanism of RNA editing is less familiar.
Abstract
The availability of complete genome sequences has made it clear that gene number is not the sole determinant of the complexity of the proteome. Additional complexity that is not readily detected by genome analysis is present in the number and types of RNA transcript that can be derived from each locus. Although alternative splicing is a well-recognized method of generating diversity, the more subtle mechanism of RNA editing is less familiar.
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