Association of apo B lipoproteins with arterial proteoglycans: pathological significance and molecular basis
G Camejo, E Hurt-Camejo, O Wiklund, G Bondjers - Atherosclerosis, 1998 - Elsevier
Retention of apo B-100 lipoproteins, low density lipoprotein (LDL) and probably lipoprotein
(a), Lp (a), by intima proteoglycans (PGs) appears to increase the residence time needed for
their structural, hydrolytic and oxidative modifications. If the rate of LDL entry exceeds the
tissue capacity to eliminate the modified products, this process may be a contributor to
atherogenesis and lesion advancement. LDL binds to PGs of the intima, by association of
specific positive segments of the apo B-100 with the negatively-charged …
(a), Lp (a), by intima proteoglycans (PGs) appears to increase the residence time needed for
their structural, hydrolytic and oxidative modifications. If the rate of LDL entry exceeds the
tissue capacity to eliminate the modified products, this process may be a contributor to
atherogenesis and lesion advancement. LDL binds to PGs of the intima, by association of
specific positive segments of the apo B-100 with the negatively-charged …