[HTML][HTML] Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia): questions, quandaries, and paradoxes
Type III hyperlipoproteinemia (HLP) is a genetic disorder characterized by accumulation of
remnant lipoproteins in the plasma and development of premature atherosclerosis. Although
receptor binding-defective forms of apolipoprotein (apo) E are the common denominator in
this disorder, a number of apparent paradoxes concerning its pathogenesis still exist.
However, studies in transgenic animals are resolving the mechanisms underlying this
disorder. Paradox I: Defective apoE (commonly apoE2) is essential but not sufficient to …
remnant lipoproteins in the plasma and development of premature atherosclerosis. Although
receptor binding-defective forms of apolipoprotein (apo) E are the common denominator in
this disorder, a number of apparent paradoxes concerning its pathogenesis still exist.
However, studies in transgenic animals are resolving the mechanisms underlying this
disorder. Paradox I: Defective apoE (commonly apoE2) is essential but not sufficient to …