[HTML][HTML] Characterization of the heparin binding sites in human apolipoprotein E
H Saito, P Dhanasekaran, D Nguyen, F Baldwin… - Journal of Biological …, 2003 - ASBMB
Apolipoprotein (apo) E mediates lipoprotein remnant clearance via interaction with cell-
surface heparan sulfate proteoglycans. Both the 22-kDa N-terminal domain and 10-kDa C-
terminal domain of apoE contain a heparin binding site; the N-terminal site overlaps with the
low density lipoprotein receptor binding region and the C-terminal site is undefined. To
understand the molecular details of the apoE-heparin interaction, we defined the
microenvironments of all 12 lysine residues in intact apoE3 and examined their relative …
surface heparan sulfate proteoglycans. Both the 22-kDa N-terminal domain and 10-kDa C-
terminal domain of apoE contain a heparin binding site; the N-terminal site overlaps with the
low density lipoprotein receptor binding region and the C-terminal site is undefined. To
understand the molecular details of the apoE-heparin interaction, we defined the
microenvironments of all 12 lysine residues in intact apoE3 and examined their relative …