[HTML][HTML] Calcium/calmodulin-dependent protein kinase II phosphorylation drives synapse-associated protein 97 into spines
Synapse-associated protein 97 (SAP97) has been involved in the correct delivery and
clustering of glutamate ionotropic receptors to the postsynaptic compartment. Here we
demonstrate that synaptic trafficking of SAP97 itself was modulated by calcium/calmodulin-
dependent protein kinase II (CaMKII) in cultured hippocampal neurons. CaMKII activation
led to increased targeting of SAP97 into dendritic spines, whereas CaMKII inhibition was
responsible for SAP97 high colocalization in the cell soma with the endoplasmic reticulum …
clustering of glutamate ionotropic receptors to the postsynaptic compartment. Here we
demonstrate that synaptic trafficking of SAP97 itself was modulated by calcium/calmodulin-
dependent protein kinase II (CaMKII) in cultured hippocampal neurons. CaMKII activation
led to increased targeting of SAP97 into dendritic spines, whereas CaMKII inhibition was
responsible for SAP97 high colocalization in the cell soma with the endoplasmic reticulum …