Context Genome-wide association studies (GWAS) have recently identified CLU, PICALM,
and CR1 as novel genes for late-onset Alzheimer disease (AD). Objectives To identify and
strengthen additional loci associated with AD and confirm these in an independent sample
and to examine the contribution of recently identified genes to AD risk prediction in a 3-stage
analysis of new and previously published GWAS on more than 35 000 persons (8371 AD
cases). Design, Setting, and Participants In stage 1, we identified strong genetic …