The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation
F D'Alessio, MW Hentze, MU Muckenthaler - Journal of hepatology, 2012 - Elsevier
BACKGROUND & AIMS: The hereditary hemochromatosis-associated membrane proteins
HFE, TfR2, and HJV are required for adequate hepatic expression of the iron hormone
hepcidin. While the genetic interactions are clear, it remains elusive how bone
morphogenetic protein co-receptor HJV functions together with HFE and TfR2 to activate
hepcidin transcription via the BMP–SMAD signaling pathway. Here, we investigate whether
HFE, TfR2, and HJV physically interact on the surface of hepatocytes. METHODS: We …
HFE, TfR2, and HJV are required for adequate hepatic expression of the iron hormone
hepcidin. While the genetic interactions are clear, it remains elusive how bone
morphogenetic protein co-receptor HJV functions together with HFE and TfR2 to activate
hepcidin transcription via the BMP–SMAD signaling pathway. Here, we investigate whether
HFE, TfR2, and HJV physically interact on the surface of hepatocytes. METHODS: We …