Complementary vascular and matrix regulatory pathways underlie the beneficial mechanism of action of sorafenib in liver fibrosis
D Thabut, C Routray, G Lomberk, U Shergill… - Hepatology, 2011 - journals.lww.com
Paracrine signaling between hepatic stellate cells (HSCs) and liver endothelial cells (LECs)
modulates fibrogenesis, angiogenesis, and portal hypertension. However, mechanisms
regulating these processes are not fully defined. Sorafenib is a receptor tyrosine kinase
inhibitor that blocks growth factor signaling in tumor cells but also displays important and not
yet fully characterized effects on liver nonparenchymal cells including HSCs and LECs. The
aim of this study was to test the hypothesis that sorafenib influences paracrine signaling …
modulates fibrogenesis, angiogenesis, and portal hypertension. However, mechanisms
regulating these processes are not fully defined. Sorafenib is a receptor tyrosine kinase
inhibitor that blocks growth factor signaling in tumor cells but also displays important and not
yet fully characterized effects on liver nonparenchymal cells including HSCs and LECs. The
aim of this study was to test the hypothesis that sorafenib influences paracrine signaling …