Portal hypertension accounts for the majority of morbidity and mortality that is encountered in
patients with cirrhosis. Portal hypertension is initiated in large part through increases in
intrahepatic vascular resistance. Fibrosis, regenerative nodule formation, and intrahepatic
vasoconstriction are classical mechanisms that account for increased intrahepatic vascular
resistance in cirrhosis. Recent data suggest that intrahepatic angiogenesis and sinusoidal
remodeling could also be involved in sinusoidal resistance, fibrosis, and portal …