[HTML][HTML] Stromal cell–derived factor-1 from biliary epithelial cells recruits CXCR4-positive cells: implications for inflammatory liver diseases
R Terada, K Yamamoto, T Hakoda, N Shimada… - Laboratory …, 2003 - Elsevier
Although stromal cell–derived factor-1 (SDF-1) plays an important role in hematopoiesis in
the fetal liver, the role after birth remains to be clarified. We investigated the role of SDF-1
and its receptor, CXCR4, in 75 patients; this included controls and patients with viral
hepatitis, liver cirrhosis, primary biliary cirrhosis, primary sclerosing cholangitis, and
autoimmune hepatitis. Interestingly, SDF-1 appeared up-regulated in biliary epithelial cells
(BEC) of inflammatory liver disease. Furthermore, in inflammatory liver diseases, SDF-1 was …
the fetal liver, the role after birth remains to be clarified. We investigated the role of SDF-1
and its receptor, CXCR4, in 75 patients; this included controls and patients with viral
hepatitis, liver cirrhosis, primary biliary cirrhosis, primary sclerosing cholangitis, and
autoimmune hepatitis. Interestingly, SDF-1 appeared up-regulated in biliary epithelial cells
(BEC) of inflammatory liver disease. Furthermore, in inflammatory liver diseases, SDF-1 was …
