DetailedAnalysis of the CD8+ T-Cell Response followingAdenovirusVaccination
We examined CD8+ T-cell expansion and function following intramuscular immunization
with a recombinant adenovirus. This study has identified a number of properties which may
explain the strong immunogenicity of adenovirus vectors:(i) the ability to deliver large
amounts of antigen into the lymphoid tissues,(ii) the ability to induce rapid expansion and
migration of CD8+ T cells throughout the lymphatics, and (iii) the ability to produce a
sustained, high-level CD8+ T-cell response.
with a recombinant adenovirus. This study has identified a number of properties which may
explain the strong immunogenicity of adenovirus vectors:(i) the ability to deliver large
amounts of antigen into the lymphoid tissues,(ii) the ability to induce rapid expansion and
migration of CD8+ T cells throughout the lymphatics, and (iii) the ability to produce a
sustained, high-level CD8+ T-cell response.
Abstract
We examined CD8+ T-cell expansion and function following intramuscular immunization with a recombinant adenovirus. This study has identified a number of properties which may explain the strong immunogenicity of adenovirus vectors: (i) the ability to deliver large amounts of antigen into the lymphoid tissues, (ii) the ability to induce rapid expansion and migration of CD8+ T cells throughout the lymphatics, and (iii) the ability to produce a sustained, high-level CD8+ T-cell response.
American Society for Microbiology