Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults
JD Walston, AM Matteini, C Nievergelt, LA Lange… - Experimental …, 2009 - Elsevier
Interleukin-6 (IL-6) is an inflammatory cytokine that influences the development of
inflammatory and aging-related disorders and ultimately longevity. In order to study the
influence of variants in genes that regulate inflammatory response on IL-6 levels and
longevity, we screened a panel of 477 tag SNPs across 87 candidate genes in> 5000 older
participants from the population-based Cardiovascular Health Study (CHS). Baseline
plasma IL-6 concentration was first confirmed as a strong predictor of all-cause mortality …
inflammatory and aging-related disorders and ultimately longevity. In order to study the
influence of variants in genes that regulate inflammatory response on IL-6 levels and
longevity, we screened a panel of 477 tag SNPs across 87 candidate genes in> 5000 older
participants from the population-based Cardiovascular Health Study (CHS). Baseline
plasma IL-6 concentration was first confirmed as a strong predictor of all-cause mortality …
