Endotoxin priming of neutrophils requires endocytosis and NADPH oxidase-dependent endosomal reactive oxygen species
FS Lamb, JS Hook, BM Hilkin, JN Huber… - Journal of Biological …, 2012 - ASBMB
NADPH oxidase 2 (Nox2)-generated reactive oxygen species (ROS) are critical for
neutrophil (polymorphonuclear leukocyte (PMN)) microbicidal function. Nox2 also plays a
role in intracellular signaling, but the site of oxidase assembly is unknown. It has been
proposed to occur on secondary granules. We previously demonstrated that intracellular
NADPH oxidase-derived ROS production is required for endotoxin priming. We
hypothesized that endotoxin drives Nox2 assembly on endosomes. Endotoxin induced ROS …
neutrophil (polymorphonuclear leukocyte (PMN)) microbicidal function. Nox2 also plays a
role in intracellular signaling, but the site of oxidase assembly is unknown. It has been
proposed to occur on secondary granules. We previously demonstrated that intracellular
NADPH oxidase-derived ROS production is required for endotoxin priming. We
hypothesized that endotoxin drives Nox2 assembly on endosomes. Endotoxin induced ROS …
