A thyroid hormone receptor α gene mutation (P398H) is associated with visceral adiposity and impaired catecholamine-stimulated lipolysis in mice
YY Liu, JJ Schultz, GA Brent - Journal of Biological Chemistry, 2003 - ASBMB
Thyroid hormone has profound effects on metabolic homeostasis, regulating both
lipogenesis and lipolysis, primarily by modulating adrenergic activity. We generated mice
with a point mutation in the thyroid hormone receptor α (TRα) gene producing a dominant-
negative TRα mutant receptor with a proline to histidine substitution (P398H). The
heterozygous P398H mutant mice had a 3.4-fold (p< 0.02) increase in serum thyrotropin
(TSH) levels. Serum triiodothyronine (T3) and thyroxine (T4) concentrations were slightly …
lipogenesis and lipolysis, primarily by modulating adrenergic activity. We generated mice
with a point mutation in the thyroid hormone receptor α (TRα) gene producing a dominant-
negative TRα mutant receptor with a proline to histidine substitution (P398H). The
heterozygous P398H mutant mice had a 3.4-fold (p< 0.02) increase in serum thyrotropin
(TSH) levels. Serum triiodothyronine (T3) and thyroxine (T4) concentrations were slightly …
