[PDF][PDF] Historical origins of transdifferentiation and reprogramming
T Graf - Cell stem cell, 2011 - cell.com
Cell stem cell, 2011•cell.com
Transcription factor-induced reprogramming of specialized cells into other cell types and to
pluripotency has revolutionized our thinking about cell plasticity, differentiation, and stem
cells. The recent advances in this area were enabled by the confluence of a number of
experimental breakthroughs that took place over the past 60 years. In this article, I give a
historical and personal perspective of the events that set the stage for our current
understanding of cellular reprogramming.
pluripotency has revolutionized our thinking about cell plasticity, differentiation, and stem
cells. The recent advances in this area were enabled by the confluence of a number of
experimental breakthroughs that took place over the past 60 years. In this article, I give a
historical and personal perspective of the events that set the stage for our current
understanding of cellular reprogramming.
Transcription factor-induced reprogramming of specialized cells into other cell types and to pluripotency has revolutionized our thinking about cell plasticity, differentiation, and stem cells. The recent advances in this area were enabled by the confluence of a number of experimental breakthroughs that took place over the past 60 years. In this article, I give a historical and personal perspective of the events that set the stage for our current understanding of cellular reprogramming.
cell.com
