[HTML][HTML] Recurrent genomic instability of chromosome 1q in neural derivatives of human embryonic stem cells
C Varela, JA Denis, J Polentes… - The Journal of …, 2012 - Am Soc Clin Investig
C Varela, JA Denis, J Polentes, M Feyeux, S Aubert, B Champon, G Piétu, M Peschanski…
The Journal of Clinical Investigation, 2012•Am Soc Clin InvestigThe evolutionary struggles from which mutants arise have been documented in almost every
living system. In this issue of the JCI, Varela and colleagues extend this list of systems to
include neural derivatives of human embryonic stem cells, which they show exhibit a
repeated gain of material from chromosome 1q. Although this raises safety issues for
therapeutic use of such cells, the frequent observation of a particular change may direct
screening strategies for detection and removal of these unwanted cellular variants.
living system. In this issue of the JCI, Varela and colleagues extend this list of systems to
include neural derivatives of human embryonic stem cells, which they show exhibit a
repeated gain of material from chromosome 1q. Although this raises safety issues for
therapeutic use of such cells, the frequent observation of a particular change may direct
screening strategies for detection and removal of these unwanted cellular variants.
Abstract
The evolutionary struggles from which mutants arise have been documented in almost every living system. In this issue of the JCI, Varela and colleagues extend this list of systems to include neural derivatives of human embryonic stem cells, which they show exhibit a repeated gain of material from chromosome 1q. Although this raises safety issues for therapeutic use of such cells, the frequent observation of a particular change may direct screening strategies for detection and removal of these unwanted cellular variants.
The Journal of Clinical Investigation