The existence of dendritic cell (DC) subsets is firmly established, but their trafficking
properties are still largely unknown. We have indicated that myeloid dendritic cells (M-DCs)
and plasmacytoid dendritic cells (P-DCs) isolated from human blood differ widely in the
capacity to migrate to chemotactic stimuli. The pattern of chemokine receptors expressed ex
vivo by both subsets is similar, but P-DCs display, compared with M-DCs, higher levels of
CC chemokine receptor (CCR) 5, CCR7, and CXCR3. Intriguingly, most chemokine …