The use of targeted mouse models for preclinical testing of novel cancer therapeutics
KP Olive, DA Tuveson - Clinical Cancer Research, 2006 - AACR
Clinical Cancer Research, 2006•AACR
The use of genetically engineered cancer-prone mice as relevant surrogates for patients
during the development of pertinent clinical applications is an unproven expectation that
awaits direct demonstration. Despite the generally disappointing findings using tumor
xenografts and certain early transgenic cancer models to predict therapeutic efficacy in
patients, the dramatic progress of mouse models in recent years engenders optimism that
the newest generation of mouse models will provide a higher standard of predictive utility in …
during the development of pertinent clinical applications is an unproven expectation that
awaits direct demonstration. Despite the generally disappointing findings using tumor
xenografts and certain early transgenic cancer models to predict therapeutic efficacy in
patients, the dramatic progress of mouse models in recent years engenders optimism that
the newest generation of mouse models will provide a higher standard of predictive utility in …
Abstract
The use of genetically engineered cancer-prone mice as relevant surrogates for patients during the development of pertinent clinical applications is an unproven expectation that awaits direct demonstration. Despite the generally disappointing findings using tumor xenografts and certain early transgenic cancer models to predict therapeutic efficacy in patients, the dramatic progress of mouse models in recent years engenders optimism that the newest generation of mouse models will provide a higher standard of predictive utility in the process of drug development.
AACR
