Polycomb complexes and silencing mechanisms
AH Lund, M van Lohuizen - Current opinion in cell biology, 2004 - Elsevier
AH Lund, M van Lohuizen
Current opinion in cell biology, 2004•ElsevierAdvances in the past couple of years have brought important new knowledge on the
mechanisms by which Polycomb-group proteins regulate gene expression and on the
consequences of their actions. The discovery of histone methylation imprints specific for
Polycomb and Trithorax complexes has provided mechanistic insight on how this ancient
epigenetic memory system acts to repress and indicates that it may share mechanistic
aspects with other silencing and genome-protective processes, such as RNA interference.
mechanisms by which Polycomb-group proteins regulate gene expression and on the
consequences of their actions. The discovery of histone methylation imprints specific for
Polycomb and Trithorax complexes has provided mechanistic insight on how this ancient
epigenetic memory system acts to repress and indicates that it may share mechanistic
aspects with other silencing and genome-protective processes, such as RNA interference.
Advances in the past couple of years have brought important new knowledge on the mechanisms by which Polycomb-group proteins regulate gene expression and on the consequences of their actions. The discovery of histone methylation imprints specific for Polycomb and Trithorax complexes has provided mechanistic insight on how this ancient epigenetic memory system acts to repress and indicates that it may share mechanistic aspects with other silencing and genome-protective processes, such as RNA interference.
Elsevier
