Histone deacetylases and cancer: causes and therapies
PA Marks, RA Rifkind, VM Richon, R Breslow… - Nature Reviews …, 2001 - nature.com
PA Marks, RA Rifkind, VM Richon, R Breslow, T Miller, WK Kelly
Nature Reviews Cancer, 2001•nature.comTogether, histone acetyltransferases and histone deacetylases (HDACs) determine the
acetylation status of histones. This acetylation affects the regulation of gene expression, and
inhibitors of HDACs have been found to cause growth arrest, differentiation and/or apoptosis
of many tumours cells by altering the transcription of a small number of genes. HDAC
inhibitors are proving to be an exciting therapeutic approach to cancer, but how do they
exert this effect?
acetylation status of histones. This acetylation affects the regulation of gene expression, and
inhibitors of HDACs have been found to cause growth arrest, differentiation and/or apoptosis
of many tumours cells by altering the transcription of a small number of genes. HDAC
inhibitors are proving to be an exciting therapeutic approach to cancer, but how do they
exert this effect?
Abstract
Together, histone acetyltransferases and histone deacetylases (HDACs) determine the acetylation status of histones. This acetylation affects the regulation of gene expression, and inhibitors of HDACs have been found to cause growth arrest, differentiation and/or apoptosis of many tumours cells by altering the transcription of a small number of genes. HDAC inhibitors are proving to be an exciting therapeutic approach to cancer, but how do they exert this effect?
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