Retinoblastoma: the disease, gene and protein provide critical leads to understand cancer
Retinoblastoma has contributed much to the understanding of cancer. The protein product of
the RB gene, pRB, is a multifaceted regulator of transcription which controls the cell cycle,
differentiation and apoptosis in normal development of specific tissues. Elucidating the
mechanisms in which pRB plays a critical role will enable novel therapies and strategies for
prevention, not only for retinoblastoma, but for cancer in general.
the RB gene, pRB, is a multifaceted regulator of transcription which controls the cell cycle,
differentiation and apoptosis in normal development of specific tissues. Elucidating the
mechanisms in which pRB plays a critical role will enable novel therapies and strategies for
prevention, not only for retinoblastoma, but for cancer in general.
Retinoblastoma has contributed much to the understanding of cancer. The protein product of the RB gene, pRB, is a multifaceted regulator of transcription which controls the cell cycle, differentiation and apoptosis in normal development of specific tissues. Elucidating the mechanisms in which pRB plays a critical role will enable novel therapies and strategies for prevention, not only for retinoblastoma, but for cancer in general.
Elsevier
