The Src-activating and signaling molecule (Srcasm) is a recently described activator and
substrate of Src-family tyrosine kinases (SFKs). When phosphorylated at specific tyrosines,
Srcasm associates with Grb2 and p85, the regulatory subunit of phosphoinositide 3-kinase;
however, little is known about the role of Srcasm in cellular signaling. Data presented here
demonstrate that epidermal growth factor (EGF) receptor ligands promote the tyrosine
phosphorylation of endogenous and adenovirally transduced Srcasm in keratinocytes, and …