Advances in the biology of astrocytomas
A Guha, J Mukherjee - Current opinion in neurology, 2004 - journals.lww.com
A Guha, J Mukherjee
Current opinion in neurology, 2004•journals.lww.comAstrocytomas, like other cancers, are a result of several molecular alterations, some of which
strongly correlate to their pathological grade. However, molecular heterogeneity exists
between astrocytomas of similar grades and likely between varying micro-environmental
regions of a single tumor. Characterization of the molecular signature of an astrocytoma and
linking with the appropriate 'tailored'therapie (s) is the hope of the future.
strongly correlate to their pathological grade. However, molecular heterogeneity exists
between astrocytomas of similar grades and likely between varying micro-environmental
regions of a single tumor. Characterization of the molecular signature of an astrocytoma and
linking with the appropriate 'tailored'therapie (s) is the hope of the future.
Summary
Astrocytomas, like other cancers, are a result of several molecular alterations, some of which strongly correlate to their pathological grade. However, molecular heterogeneity exists between astrocytomas of similar grades and likely between varying micro-environmental regions of a single tumor. Characterization of the molecular signature of an astrocytoma and linking with the appropriate ‘tailored’therapie (s) is the hope of the future.
Lippincott Williams & Wilkins