Interleukin-1
CA Dinarello - Cytokine & growth factor reviews, 1997 - Elsevier
Interleukin-I (IL-1) is the prototypic pro-inflammatory cytokine. There are two forms of IL-1, IL-
1α and IL-Iβ and in most studies, their biological activities are indistinguishable. IL-1 affects
nearly every cell type, often in concert with another pro-inflammatory cytokine, tumor
necrosis factor (TNF). Although IL-1 can upregulate host defenses and function as an
immunoadjuvant, IL-1 is a highly inflammatory cytokine. The margin between clinical benefit
and unacceptable toxicity in humans is exceedingly narrow. In contrast, agents that reduce …
1α and IL-Iβ and in most studies, their biological activities are indistinguishable. IL-1 affects
nearly every cell type, often in concert with another pro-inflammatory cytokine, tumor
necrosis factor (TNF). Although IL-1 can upregulate host defenses and function as an
immunoadjuvant, IL-1 is a highly inflammatory cytokine. The margin between clinical benefit
and unacceptable toxicity in humans is exceedingly narrow. In contrast, agents that reduce …
