Role of glucagon and insulin in control of glucose turnover
A Cherrington, M Vranic - Metabolism, 1971 - Elsevier
A Cherrington, M Vranic
Metabolism, 1971•ElsevierThe effects of a concurrent supply of glucagon and insulin were investigated in five
conscious postabsorptive dogs whose insulin secretion was replaced by a near-basal
intraportal insulin infusion of 240 μU/kg/min. An infusion of 29 mμg/kg/min of glucagon with a
simultaneous 12-fold increase in the rate of insulin supply doubled the turnover of glucose
with a small change in its concentration. This minicked the effect of glucagon infusions in five
normal dogs. In contrast, four-to eightfold increases in insulin supply did not match the effect …
conscious postabsorptive dogs whose insulin secretion was replaced by a near-basal
intraportal insulin infusion of 240 μU/kg/min. An infusion of 29 mμg/kg/min of glucagon with a
simultaneous 12-fold increase in the rate of insulin supply doubled the turnover of glucose
with a small change in its concentration. This minicked the effect of glucagon infusions in five
normal dogs. In contrast, four-to eightfold increases in insulin supply did not match the effect …
Abstract
The effects of a concurrent supply of glucagon and insulin were investigated in five conscious postabsorptive dogs whose insulin secretion was replaced by a near-basal intraportal insulin infusion of 240 μU/kg/min. An infusion of 29 mμg/kg/min of glucagon with a simultaneous 12-fold increase in the rate of insulin supply doubled the turnover of glucose with a small change in its concentration. This minicked the effect of glucagon infusions in five normal dogs. In contrast, four- to eightfold increases in insulin supply did not match the effect of glucagon in the depancreatized dogs. The rate of glucose production exceeded its rate of utilization and hyperglycemia resulted promptly.
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