Regulation of lymphocyte development by Notch signaling
K Tanigaki, T Honjo - Nature immunology, 2007 - nature.com
K Tanigaki, T Honjo
Nature immunology, 2007•nature.comNotch molecules are well conserved from Drosophila melanogaster to mammals and
regulate a broad spectrum of various cell lineage commitment processes. Recent studies
using inhibitors, transgenic mice and conditional loss-of-function approaches have
demonstrated essential roles for Notch signaling in the differentiation of thymocytes and
peripheral T cells, as well as B cells. Here we highlight parallels in the developmental
regulation of mammalian lymphocytes and the D. melanogaster nervous system through …
regulate a broad spectrum of various cell lineage commitment processes. Recent studies
using inhibitors, transgenic mice and conditional loss-of-function approaches have
demonstrated essential roles for Notch signaling in the differentiation of thymocytes and
peripheral T cells, as well as B cells. Here we highlight parallels in the developmental
regulation of mammalian lymphocytes and the D. melanogaster nervous system through …
Abstract
Notch molecules are well conserved from Drosophila melanogaster to mammals and regulate a broad spectrum of various cell lineage commitment processes. Recent studies using inhibitors, transgenic mice and conditional loss-of-function approaches have demonstrated essential roles for Notch signaling in the differentiation of thymocytes and peripheral T cells, as well as B cells. Here we highlight parallels in the developmental regulation of mammalian lymphocytes and the D. melanogaster nervous system through Notch cooperation with the transcriptional regulators RBP-J (Su(H)), MINT (Hairless) and E2A (Ac-Sc–Da).
nature.com
