TACI, an enigmatic BAFF/APRIL receptor, with new unappreciated biochemical and biological properties
F Mackay, P Schneider - Cytokine & growth factor reviews, 2008 - Elsevier
BAFF is a B cell survival factor that binds to three receptors BAFF-R, TACI and BCMA. BAFF-
R is the receptor triggering naïve B cell survival and maturation while BCMA supports the
survival of plasma cells in the bone marrow. Excessive BAFF production leads to
autoimmunity, presumably as the consequence of inappropriate survival of self-reactive B
cells. The function of TACI has been more elusive with TACI−/− mice revealing two sides of
this receptor, a positive one driving T cell-independent immune responses and a negative …
R is the receptor triggering naïve B cell survival and maturation while BCMA supports the
survival of plasma cells in the bone marrow. Excessive BAFF production leads to
autoimmunity, presumably as the consequence of inappropriate survival of self-reactive B
cells. The function of TACI has been more elusive with TACI−/− mice revealing two sides of
this receptor, a positive one driving T cell-independent immune responses and a negative …
