Differential glycosylation of polymeric and monomeric IgA: a possible role in glomerular inflammation in IgA nephropathy
BD Oortwijn, A Roos, L Royle… - Journal of the …, 2006 - journals.lww.com
IgA nephropathy (IgAN) is characterized by mesangial deposition of polymeric IgA1 (pIgA1)
and complement. Complement activation via mannose-binding lectin and the lectin pathway
is associated with disease progression. Furthermore, recent studies have indicated a
possible role for secretory IgA. IgAN is associated with abnormalities in circulating IgA,
including aberrant O-linked glycosylation. This study characterized and compared functional
properties and N-linked glycosylation of highly purified monomeric IgA (mIgA) and pIgA from …
and complement. Complement activation via mannose-binding lectin and the lectin pathway
is associated with disease progression. Furthermore, recent studies have indicated a
possible role for secretory IgA. IgAN is associated with abnormalities in circulating IgA,
including aberrant O-linked glycosylation. This study characterized and compared functional
properties and N-linked glycosylation of highly purified monomeric IgA (mIgA) and pIgA from …
