[HTML][HTML] Apolipoprotein L1, a novel Bcl-2 homology domain 3-only lipid-binding protein, induces autophagic cell death
G Wan, S Zhaorigetu, Z Liu, R Kaini, Z Jiang… - Journal of biological …, 2008 - ASBMB
The Bcl-2 family proteins are important regulators of type I programmed cell death apoptosis;
however, their role in autophagic cell death (AuCD) or type II programmed cell death is still
largely unknown. Here we report the cloning and characterization of a novel Bcl-2 homology
domain 3 (BH3)-only protein, apolipoprotein L1 (apoL1), that, when overexpressed and
accumulated intracellularly, induces AuCD in cells as characterized by the increasing
formation of autophagic vacuoles and activating the translocation of LC3-II from the cytosol …
however, their role in autophagic cell death (AuCD) or type II programmed cell death is still
largely unknown. Here we report the cloning and characterization of a novel Bcl-2 homology
domain 3 (BH3)-only protein, apolipoprotein L1 (apoL1), that, when overexpressed and
accumulated intracellularly, induces AuCD in cells as characterized by the increasing
formation of autophagic vacuoles and activating the translocation of LC3-II from the cytosol …