Genome-wide association studies in type 1 diabetes, inflammatory bowel disease and other immune-mediated disorders
H Hakonarson, SFA Grant - Seminars in Immunology, 2009 - Elsevier
Seminars in Immunology, 2009•Elsevier
Genome-wide association studies have delivered on the promise of uncovering genetic
determinants of complex disease. In this review, we provide a summary of recent advances
in the identification of multiple variants associated with autoimmune-mediated disorders;
specifically type 1 diabetes and inflammatory bowel disease. Sixteen loci, all replicated in
independent samples, have now been uncovered for type 1 diabetes and in excess of 40 for
inflammatory bowel disease. The next steps are to identify the true causal variants …
determinants of complex disease. In this review, we provide a summary of recent advances
in the identification of multiple variants associated with autoimmune-mediated disorders;
specifically type 1 diabetes and inflammatory bowel disease. Sixteen loci, all replicated in
independent samples, have now been uncovered for type 1 diabetes and in excess of 40 for
inflammatory bowel disease. The next steps are to identify the true causal variants …
Genome-wide association studies have delivered on the promise of uncovering genetic determinants of complex disease. In this review, we provide a summary of recent advances in the identification of multiple variants associated with autoimmune-mediated disorders; specifically type 1 diabetes and inflammatory bowel disease. Sixteen loci, all replicated in independent samples, have now been uncovered for type 1 diabetes and in excess of 40 for inflammatory bowel disease. The next steps are to identify the true causal variants underlying evidence of disease association and to leverage this information to improve diagnosis, prevention and cure of these diseases.
Elsevier