Microglial activation in human diabetic retinopathy
H Zeng, WR Green, MOM Tso - Archives of ophthalmology, 2008 - jamanetwork.com
Objective To investigate microglial activation in human diabetic retinopathy. Methods
Paraffin sections from 21 eyes of 13 patients with diabetic background, preproliferative, or
proliferative retinopathies and 10 normal eyes of 9 individuals were studied with
immunolabeling of microglia with antibodies against HLA-DR antigen, CD45, or CD68.
Results In the healthy human eyes, ramified microglial cells were scattered in the inner
retinal layers. In eyes with diabetic retinopathy, the microglia were markedly increased in …
Paraffin sections from 21 eyes of 13 patients with diabetic background, preproliferative, or
proliferative retinopathies and 10 normal eyes of 9 individuals were studied with
immunolabeling of microglia with antibodies against HLA-DR antigen, CD45, or CD68.
Results In the healthy human eyes, ramified microglial cells were scattered in the inner
retinal layers. In eyes with diabetic retinopathy, the microglia were markedly increased in …