[HTML][HTML] Novel DNA binding by a basic helix-loop-helix protein: the role of the dioxin receptor PAS domain
A Chapman-Smith, ML Whitelaw - Journal of biological chemistry, 2006 - ASBMB
Central issues surrounding the basic helix-loop-helix (bHLH) superfamily of dimeric
transcription factors concern how specificity of partner selection and DNA binding are
achieved. bHLH proteins bind DNA through the basic sequence that is contiguous with a
helix-loop-helix dimerization domain. For the two subgroups within the family, dimerization is
further regulated by an adjacent Per-Arnt-Sim homology (PAS) or leucine zipper (LZ)
domain. We provide evidence that for the bHLH· PAS transcription factors Dioxin Receptor …
transcription factors concern how specificity of partner selection and DNA binding are
achieved. bHLH proteins bind DNA through the basic sequence that is contiguous with a
helix-loop-helix dimerization domain. For the two subgroups within the family, dimerization is
further regulated by an adjacent Per-Arnt-Sim homology (PAS) or leucine zipper (LZ)
domain. We provide evidence that for the bHLH· PAS transcription factors Dioxin Receptor …