[HTML][HTML] Nitrogen Dioxide Inducescis-trans-Isomerization of Arachidonic Acid within Cellular Phospholipids: DETECTION OF TRANS-ARACHIDONIC ACIDS IN VIVO
H Jiang, N Kruger, DR Lahiri, D Wang… - Journal of Biological …, 1999 - ASBMB
Oxygen free radicals oxidize arachidonic acid to a complex mixture of metabolites termed
isoeicosanoids that share structural similarity to enzymatically derived eicosanoids.
However, little is known about oxidations of arachidonic acid mediated by reactive radical
nitrogen oxides. We have studied the reaction of arachidonic acid with NO 2, a free radical
generated by nitric oxide and nitrite oxidations. A major group of products appeared to be a
mixture of arachidonic acid isomers having onetrans-bond and three cis-double bonds. We …
isoeicosanoids that share structural similarity to enzymatically derived eicosanoids.
However, little is known about oxidations of arachidonic acid mediated by reactive radical
nitrogen oxides. We have studied the reaction of arachidonic acid with NO 2, a free radical
generated by nitric oxide and nitrite oxidations. A major group of products appeared to be a
mixture of arachidonic acid isomers having onetrans-bond and three cis-double bonds. We …