Differential response in the release of hydrogen peroxide between astroglial cells and endothelial cells following hypoxia/reoxygenation
T Kondo, H Kinouchi, M Kawase, T Yoshimoto - Neuroscience letters, 1996 - Elsevier
T Kondo, H Kinouchi, M Kawase, T Yoshimoto
Neuroscience letters, 1996•ElsevierHydrogen peroxide (H202) and lactate dehydrogenase (LDH) released from cultured
astroglial cells (AGs) and brain endothelial cells (BECs) were measured following
hypoxia/reoxygenation. AGs released H202 to the extracellular space from 8 h of hypoxia
with the cellular injury indicated by LDH increase. In contrast, BECs released H202 at 4 h of
hypoxia, prior to the LDH increase. These results suggest that AGs and BECs play different
roles in production and metabolism of oxygen free radicals in the blood-brain barrier (BBB) …
astroglial cells (AGs) and brain endothelial cells (BECs) were measured following
hypoxia/reoxygenation. AGs released H202 to the extracellular space from 8 h of hypoxia
with the cellular injury indicated by LDH increase. In contrast, BECs released H202 at 4 h of
hypoxia, prior to the LDH increase. These results suggest that AGs and BECs play different
roles in production and metabolism of oxygen free radicals in the blood-brain barrier (BBB) …
Hydrogen peroxide (H202) and lactate dehydrogenase (LDH) released from cultured astroglial cells (AGs) and brain endothelial cells (BECs) were measured following hypoxia/reoxygenation. AGs released H202 to the extracellular space from 8 h of hypoxia with the cellular injury indicated by LDH increase. In contrast, BECs released H202 at 4 h of hypoxia, prior to the LDH increase. These results suggest that AGs and BECs play different roles in production and metabolism of oxygen free radicals in the blood-brain barrier (BBB), and AGs may protect the BBB disruption from oxidative stress after hypoxia/reoxygenation.
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