Tocopherol efficacy and safety for preventing retinopathy of prematurity: a randomized, controlled, double-masked trial
DL Phelps, AL Rosenbaum, SJ lsenberg… - …, 1987 - publications.aap.org
To test the efficacy and safety of vitamin E in preventing retinopathy of prematurity, 287
infants with birth weights of less than 1.5 kg or gestational ages of less than 33 weeks were
enrolled within 24 hours of birth in a randomized, double-masked trial of IV, followed by oral,
placebo v tocopherol (adjusted to plasma levels of 3 to 3.5 mg/dL). In the 196 infants
completing ophthalmic follow-up, tocopherol did not prevent retinopathy of prematurity of
any stage (28% placebo treated v 26% tocopherol treated) or moderately severe retinopathy …
infants with birth weights of less than 1.5 kg or gestational ages of less than 33 weeks were
enrolled within 24 hours of birth in a randomized, double-masked trial of IV, followed by oral,
placebo v tocopherol (adjusted to plasma levels of 3 to 3.5 mg/dL). In the 196 infants
completing ophthalmic follow-up, tocopherol did not prevent retinopathy of prematurity of
any stage (28% placebo treated v 26% tocopherol treated) or moderately severe retinopathy …