B-cell delivered gene transfer of human S-Ag-Ig fusion protein protects from experimental autoimmune uveitis
W Liang, Z Karabekian, Q Xu, AM Viley, DW Scott - Clinical Immunology, 2006 - Elsevier
Uveitis is an important autoimmune disease affecting an estimated 2.3 million Americans.
This disease is manifested by inflammation of the retina mediated by the infiltration of T
lymphocytes that recognize “S-Antigen”(S-Ag). Current therapies involve the life-long use of
immunosuppressive drugs, including steroids. The ability to induce specific tolerance to S-
Ag would be desirable and allow patients to be weaned off of steroid therapy. In this study,
we determined that S-Ag-Ig retroviral vector was capable of preventing EAU (experimental …
This disease is manifested by inflammation of the retina mediated by the infiltration of T
lymphocytes that recognize “S-Antigen”(S-Ag). Current therapies involve the life-long use of
immunosuppressive drugs, including steroids. The ability to induce specific tolerance to S-
Ag would be desirable and allow patients to be weaned off of steroid therapy. In this study,
we determined that S-Ag-Ig retroviral vector was capable of preventing EAU (experimental …