Complete association of the HLA-DRB1∗ 04 and-DQB1∗ 04 alleles with Vogt-Koyanagi-Harada's disease
Y Shindo, S Ohno, T Yamamoto, S Nakamura… - Human immunology, 1994 - Elsevier
VKH disease is a bilateral panuveitis and has been known to be closely associated with the
particular HLA class II antigens HLA-DR4 and-DQ4, defined by serologic typing. In this
study, 63 Japanese VKH patients were analyzed for HLA class II alleles at the DNA level
using the PCR-RFLP method. The DRB1∗ 04 alleles encoding the serologic specificity DR4
were found in 100% of the VKH patients carrying DRB1∗ 0405 or DRB1∗ 0410. By
statistical analysis, only DRB1∗ 0405 was found to be significantly increased as compared …
particular HLA class II antigens HLA-DR4 and-DQ4, defined by serologic typing. In this
study, 63 Japanese VKH patients were analyzed for HLA class II alleles at the DNA level
using the PCR-RFLP method. The DRB1∗ 04 alleles encoding the serologic specificity DR4
were found in 100% of the VKH patients carrying DRB1∗ 0405 or DRB1∗ 0410. By
statistical analysis, only DRB1∗ 0405 was found to be significantly increased as compared …