HLA-A29. 2 subtype associated with birdshot retinochoroidopathy
P LeHoang, N Ozdemir, A Benhamou, T Tabary… - American journal of …, 1992 - Elsevier
P LeHoang, N Ozdemir, A Benhamou, T Tabary, C Edelson, H Betuel, R Semiglia…
American journal of ophthalmology, 1992•ElsevierBirdshot retinochoroidopathy is strongly associated with HLA-A29. This antigen can be
divided into two subtypes, A29. 1 and A29. 2, using an immunoprecipitation method
succeeded by one-dimensional electrofocusing gel electrophoresis. We reviewed the HLA
typings of 58 white French patients who had birdshot retinochoroidopathy. Of these 58
subjects, 54 (93.1%) had HLA-A29 with a relative risk of 157.30. We further analyzed the
HLA-A29 subtypings of 33 patients with birdshot retinochoroidopathy. Evaluation of the …
divided into two subtypes, A29. 1 and A29. 2, using an immunoprecipitation method
succeeded by one-dimensional electrofocusing gel electrophoresis. We reviewed the HLA
typings of 58 white French patients who had birdshot retinochoroidopathy. Of these 58
subjects, 54 (93.1%) had HLA-A29 with a relative risk of 157.30. We further analyzed the
HLA-A29 subtypings of 33 patients with birdshot retinochoroidopathy. Evaluation of the …
Birdshot retinochoroidopathy is strongly associated with HLA-A29. This antigen can be divided into two subtypes, A29.1 and A29.2, using an immunoprecipitation method succeeded by one-dimensional electrofocusing gel electrophoresis. We reviewed the HLA typings of 58 white French patients who had birdshot retinochoroidopathy. Of these 58 subjects, 54 (93.1%) had HLA-A29 with a relative risk of 157.30. We further analyzed the HLA-A29 subtypings of 33 patients with birdshot retinochoroidopathy. Evaluation of the results showed that HLA-A29.2 subtype was present in all patients (100%). We concluded that the absence of HLA-A29.1 subtype is statistically significant (P < .01) in this study of HLA-A29 subtyping.
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