One of the hallmarks of age-related macular degeneration (AMD), the leading cause of
blindness in the elderly in Western societies, is the accumulation of sub-retinal pigment
epithelial deposits (sub-RPE deposits), including drusen and basal laminar deposits, in
Bruch's membrane (BM). The nature and the underlying mechanisms of this deposit
formation are not fully understood. Because we know that zinc contributes to deposit
formation in neurodegenerative diseases, we tested the hypothesis that zinc might be …