The endogenous cannabinoid system participates in the regulation of energy homeostasis,
and this fact led to the identification of a new group of therapeutic agents for complicated
obesity and diabetes. Cannabinoid receptor antagonists are now realities in clinical practice.
The use of such antagonists for reducing body weight gain, lowering cholesterol and
improving glucose homeostasis is based on the ability of the endocannabinoids to
coordinately regulate energy homeostasis by interacting with central and peripheral targets …