[HTML][HTML] Emerging functions of basophils in protective and allergic immune responses
CL Sokol, R Medzhitov - Mucosal immunology, 2010 - Elsevier
Basophils that were long thought to have a redundant role in mast cells in the effector
response to allergens and parasites are now being recognized to have important roles in the
regulation of adaptive immune responses. Recent data have revealed their role in the
initiation of the T helper cell 2 (Th2)-mediated immune response. Not only do basophils
guide the Th1–Th2 balance by providing an early source of crucial Th2-skewing cytokines,
interleukin (IL)-4 and thymic stromal lymphopoietin, but recent findings have also illustrated …
response to allergens and parasites are now being recognized to have important roles in the
regulation of adaptive immune responses. Recent data have revealed their role in the
initiation of the T helper cell 2 (Th2)-mediated immune response. Not only do basophils
guide the Th1–Th2 balance by providing an early source of crucial Th2-skewing cytokines,
interleukin (IL)-4 and thymic stromal lymphopoietin, but recent findings have also illustrated …