Oxygenation status of malignant tumors: pathogenesis of hypoxia and significance for tumor therapy
P Vaupel, DK Kelleher, M Höckel - Seminars in oncology, 2001 - Elsevier
Hypoxic areas are a characteristic property of solid tumors. Hypoxia results from an
imbalance between the supply and consumption of oxygen. Major pathogenetic
mechanisms for the emergence of hypoxia are (1) structural and functional abnormalities in
the tumor microvasculature;(2) an increase in diffusion distances; and (3) tumor-or therapy-
associated anemia leading to a reduced O2 transport capacity of the blood. There is
pronounced intertumor variability in the extent of hypoxia, which is independent of clinical …
imbalance between the supply and consumption of oxygen. Major pathogenetic
mechanisms for the emergence of hypoxia are (1) structural and functional abnormalities in
the tumor microvasculature;(2) an increase in diffusion distances; and (3) tumor-or therapy-
associated anemia leading to a reduced O2 transport capacity of the blood. There is
pronounced intertumor variability in the extent of hypoxia, which is independent of clinical …